effects of co-administration of ghrelin agonist (ghrp-2) and gh on tnf-α, il-6 and inos gene expression induced by lps in the mouse brain
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abstract
the aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (ghrp-2) and growth hormone (gh) on tumor necrosis factor-α (tnf-α),interleukin-6 (il-6) and inducible nitric oxide synthase (inos) gene expression induced by lps in the mousebrain. thirty-five male nmri mice (25±5 g) were injected through the mouse tail vein with saline, ghrp-2(100 μg/kg), gh (25 μg/kg) or ghrp-2 + gh, 30 min before the intraperitoneal injection of lps (5 mg/kg).then, inflammation was induced by the intraperitoneal injection of lps. the control animals received sterilesaline in the first and second injections. changes in the expression level of tnf-α, il-6 and inos geneswere studied in the mouse brain by a semi quantitative rt-pcr method. the results of this study showedthat ghrp-2 or gh significantly decreased the expression of tnf-α and il-6 genes in brain 2 h after theinjection of lps. co-administration of ghrp-2 and gh markedly reduced the expression of tnf-α and il-6genes. lps had no effect on the expression of inos gene in brain. the data suggest that co-administration of ghrp-2 and gh has a protective effect in brain inflammation induced by lps through inhibition of tnf-αand il-6.
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Journal title:
iranian journal of veterinary researchPublisher: shiraz university
ISSN 1728-1997
volume 14
issue 4 2013
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